WHAT ARE THE BIGGEST BENEFITS?

Making particle size analysis highly efficient

Capture the real-time data analysis of your bulk powder processes automatically with our powder and bulk solid particle size analyzer. Troubleshoot and improve end-product goals with particle size and shape data. Adopt automated process control to drive down production cost. Non-product contact automation minimises risk with hazardous materials.

Seize intelligent innovation Eyecon

GAIN THE COMPETITIVE EDGE

Seize intelligent innovation

Manufacturers are leveraging more data into operations by embedding intelligent devices to increase functionality. Eyecon2 is Pharma 4.0 ready and compatible with the connected devices mantra of the Internet of Things. Using direct image analysis, our particle size analyzer can deliver more efficiency and accuracy than laser diffraction technology to measure particles.

ADAPTIVE TECHNOLOGY

Operational flexibility

Eyecon2 particle analyser can be implemented anywhere powders flow. In-line, non-product contact measurement for both Batch and Continuous processes, removing the need for sampling. Optimise product transfer and scale-up, Eyecon2 can follow and define the journey from lab to pilot to production scale, saving time and cost.

Eyecon2 operational flexiblity
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TAKING EFFICACY FURTHER

Build quality control into the process

Eyecon2 underpins QbD by affording the ability to control and predict critical quality attributes (CQAs). Knowledge of particle size and shape reveals the functional relationships linking material attributes and critical process parameters (CPPs). Eyecon2 is an enabler of Continuous Process Verification.

Technical Specifications

 

Measurement

Size Range 50 - 5500 μm
Principle Measurement Method (non-product contact) Direct Imaging
Size Measurement Data D10, D25, D50, D75, D90 in numeric and volumetric with Mean and Median values all trended in real time with live histogram and S-curve results. Includes process deviation alarm. 
Shape Measurement Data Eccentricity Average, Eccentricity RSD, Range 0-1
Exportable Data PDF report of recording session, CSV file with data on every image analysed with full PSD from D5-D95, captured images exportable as JPEG
Data Processing EyePASSTM real time particle analysis software installed on a dedicated IPC/PC/Laptop with Windows 10
Measurement Time ~ 5 seconds per image
Material Speed (max.) ≈ 10 m/sec

Physical

Dimensions & Weight Eyecon2 250 x 128 x 132 mm (4 kg)

Connection Hub 254 x 170 x 57 mm (1.2 kg)
  Eyecon2 inc. Automated Benchtop Stage 300 x 190 x 480 mm (7.8 kg)
Power 230VAC @ 50HZ / 110VAC @ 60HZ  
Casing Materials 304 Stainless steel, Glass window, Silicon gaskets  
Connection Cable From Eyecon2 to Connections Hub via Speedcon quick-release power & data cable, available in lengths up to 25 m. From Connections Hub to IPC/Laptop via USB  

Imaging

Illumination Source 12x3 High intensity, low energy R,G,B LEDs
Image Area 11.25 mm x 11.25 mm
Pixel Size 5.5 μm x 5.5 μm
Resolution 2046 px x 2046 px
Exposure Duration 5 μs
Sensor CMOS

 

Software

GMP EyePASS is both 21 CFR part 11 & GAMP5 Compliant
Communications

EyePASS is Open Platform Communications compatible with OPC UA & OPC DA 3
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Application Notes

Method of particle size determination - review by Innopharma Technology

Methods of Particle Size Determination – A Review

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EyeCon2

EyeCon2 Product Brochure

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An Automated Control Strategy for Wurster Coating to Reduce Dissolution Variability due to Raw Material Variations

An Automated Control Strategy for Wurster Coating to Reduce Dissolution Variability due to Raw Material Variation

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Particle Size Analysis of 2 – 5 mm Particles of Varying Colour from Coating and Granulation Processes using Process Analytical Technology

Particle Size Analysis of 2 – 5 mm Particles of Varying Colour from Coating and Granulation Processes using Process Analytical Technology

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A Guide to D-values in Pharmaceutical Particle Characterisation

A Guide to D-values in Pharmaceutical Particle Characterisation

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The use of Real-Time At-Line Particle Size Measurement on a Pelletization Process for Accurate End-Point Prediction

The use of Real-Time At-Line Particle Size Measurement on a Pelletization  Process for Accurate End-Point Prediction

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Unique Advantages of Process Analytical Technology in Twin-Screw Granulation

Unique Advantages of Process Analytical Technology in Twin-Screw Granulation

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Real-Time In-Line Monitoring of the Impact of Process Parameter Changes on Critical Quality Attributes in Fluid Bed Granulation using Process Analytical Technology

Real-Time In-Line Monitoring of the Impact of Process Parameter Changes on Critical Quality Attributes in Fluid Bed Granulation using Process Analytical Technology

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Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology

Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology

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Implementation of PAT for In-Line Monitoring of a Milling Process During DoE for Continuous Processing

Implementation of PAT for In-Line Monitoring of a Milling Process During DoE for Continuous Processing

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GET A HELPING HAND

End-to-end integration support

With Innopharma Technology’s team of mechanical, electronic, and application engineers, we have extensive experience collaborating with process experts to achieve successful measurement and process integration solutions from the equipment level with Eyecon2, to integration with automated software platforms, such as SmartX, for advanced process control.

Avail of our trial facility

GAIN INSIGHT INTO YOUR MATERIAL

Avail of our trial facility

For peace of mind, we invite customers to undertake a trial of their material at our Ireland application lab (with optional customer attendance). Where we offer sample analysis with Eyecon2 particle size analyzer. Trials can also replicate real-world conditions with a wide range of processing equipment available to offer assurance that Eyecon2 can meet their analytical requirements.

LET’S START A CONVERSATION

Putting particle size technology to work

We at Innopharma Technology work with industry scientists and engineers to understand the challenges they face, and the risks when embedding new technology. Whether it’s a standard benchtop system or a custom In-line design, Innopharma Technology aims to help facilities get to market faster, improve process understanding and achieve higher standards of quality by offering versatile solutions suited to their needs.

Putting particle size technology to work
Eyecon accessories services

ADD VALUE FROM DAY-1

Accessories and Services

We help customers unlock the full potential of Eyecon2 by offering a number of accessories and services. On-site training ensures users are confident with the technology, while top-notch customer support and extended maintenance contracts ensure you’re never more than a phone call away from help when needed. A Verification Standards Kit (VSK) offers an easy, traceable and certified method for system calibration/verification, and our IQ OQ template streamlines the qualification process, with optional on-site execution by our own expert engineers.

OPTIMISE PROCESSES WITH AI

Measure Particle Size with AI and Machine Learning

Eyecon2 , our non-product contact, real time particle size and shape data analyser has had a significant software upgrade. EyePASS the particle size image analysis software now utilizes cutting edge Artificial Intelligence (AI) and machine learning.

At-line Eyecon2

Particle Analyses Functionality

Capture the real-time data analysis and profile of your dry powders and bulk solids with Eyecon2 particle size analyser. Troubleshoot and improve end-product goals with particle size and shape data. Adopt automated process control to drive down production cost. Non-product contact measurement minimizes risk with hazardous materials. At-line and in-line configurations allow transition from benchtop to in-line integration and evolve with your needs. EyePASS the Image analysis software now utilizes cutting edge Artificial Intelligence (AI) and Machine Learning (ML)

Advances in Machine Learning

The AI upgrade transforms the versatility of the Eyecon2, vastly expanding the range of material types that can be measured in real time and drastically improves particle size and shape detection for materials that were previously unviable for image analysis. One of the primary steps performed by our image analysis software EyePASS is particle segmentation i.e., the detection and delineation of particles from the images sent by the Eyecon2. All measurements reported by the software are based on the results of the particle segmentation step.

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Benefits of Machine Learning AI

Convolutional neural networks (CNN) iterate the trained images, assigns weights and biases to assorted objects in the image, differentiate one from the other and improves the feature of interest extraction from new unseen image data. This means EyePASS V 3.0 with ML image analysis unlocks the full power of particle size and shape analysis. ML image analysis negates difficulties with the traditional computer vision constraints of illumination and classification of materials with light absorption or light reflective properties. i.e dark materials, reflective materials etc. can now be measured for particle size distribution.

START A CONVERSATION

 
 
   
 
 
 

Testimonials

The Eyecon is outstanding in measuring in-process particle size during the granulation and particle coating processes. We also integrated this technology into our control systems, as part of a Process Analytical Technology package desired by some of our clients.

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Ed Godek | Process Technology Manager | Glatt Air Techniques, Inc.

While using the Multieye to measure roller compaction ribbons, we observed an excellent correlation between the NIR spectra and off-line density results.

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Abina Crean | Lecturer in Pharmaceutics | University College Cork

Eyecon₂ with its automated high-speed image analysis is implemented to accurately predict the process end-point with fast objective PSD data, supported by particle images, to significantly improve process optimisation and control.

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Thomas Hoffmeir | Head of Business Unit - Process Technology Pharma | Glatt GmbH

Using the Multieye we have the capability to beautifully monitor the moisture trend in real-time, during the liquid addition and drying process in a fluid bed granulation process.

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Denisio Togashi | Post-Doctoral Researcher | Dublin Institute of Technology

More and more high-end Chinese pharmaceutical manufacturers are aware of and actively seeking to implement QbD principals into their manufacturing processes. Implementation of Eyecon₂ optimises FBP design and subsequently enables increased process understanding.

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Arthur Rong | Vice Manager - Oral Solid Dosage | Austar

Before we had any PAT tools, the process was like a black box to us. We put something in and get something out without knowing what happened inside. Now, we have an ‘Eye’ to look inside that black box and see what’s going on in there.

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Deron HE | General Manager - Smart Manufacturing | Chanse Technology (Jiangsu) Inc.

Organisations we have worked with…

Glatt
TU DUBLIN
CHANSE
AUSTAR
purdue 
RUTGERS UNIVERSITY
servier