An Automated Control Strategy for Wurster Coating to Reduce Dissolution Variability due to Raw Material Variations

Extended or modified release formulations are becoming more and more common within the pharmaceutical industry due to their advantages for patient compliance and efficacy. Manufactured using fluid bed coating, the process is typically controlled by spraying a fixed quantity of release coating on the drug loaded substrate as a means of achieving the desired dissolution profile. In this work a control method is explored whereby real-time size measurements of the in-process particles are used to gauge the true thickness of the release coating, and thereby determine when the end of spraying has been reached.


Download Now

 
 
   
 
 
 
an-automated-control-strategy-for-wurster-coating-to-reduce-dissolution-variabilit.pdf
Thank you for your interest in our whitepapers. Your download should start automatically.

Organisations we have worked with…

Glatt
TU DUBLIN
CHANSE
AUSTAR
purdue 
RUTGERS UNIVERSITY
servier